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Endocrine Abstracts

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ea0090p708 | Pituitary and Neuroendocrinology | ECE2023

Congenital, isolated, and lifetime growth hormone deficiency provides superior cognitive performance in senescence

Batista Vanderlan O. , Kellner Michael , Salvatori Roberto , Oliveira Walter , Faro Andre , Santos Lucas B. , Melo Enaldo V. , Oliveira-Santos Alecia A. , Oliveira Carla R. P. , Almeida Viviane , Barros-Oliveira Cynthia S. , Santos Elenilde G. , Santana Nathalie O. , Villar-Gouy Keila R. , Leal Angela , Amorim Rivia S. , H. Aguiar-Oliveira Manuel

Mice with isolated GH deficiency (IGHD) due to GHRH receptor mutations live longer than their normal siblings with an extended healthspan, i.e., the period of life free from disabilities. Human IGHD individuals due to a mutation in the GHRH receptor gene from Itabaianinha, Brazil, has a normal lifespan with an extended healthspan (1). Our hypothesis is that their aging is accompanied by a delayed cognitive decline. Accordingly, we used the Literacy Independent Cognitive Assess...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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